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Fig. 2 | One Health Outlook

Fig. 2

From: Experimental cross-species infection of donkeys with equine hepacivirus and analysis of host immune signatures

Fig. 2

Morphological findings in liver biopsies from donkeys pre- and post- infection with EqHV. A-D Histologically, a mild periportally-accentuated, lympho-histiocytic inflammation was detected within liver biopsies with a similar appearance in samples taken pre- (A, C) and post- (B, D) infection. Hematoxylin and eosin, scale bar = 100 μm. E-P Inflammatory cell infiltrates consisted mainly of T-lymphocytes (E-H, asterisk), fewer macrophages (I-L, asterisk) and single B-lymphocytes (M-P, asterisk) pre- and post-infection. Immunohistochemistry, scale bar = 100 μm. Q-T Fluorescence in situ-hybridization lacked a positive reaction pre-infection (Q, S). Post-infection, EqHV specific RNA sequences were detected within the cytoplasm (R, T). Scale bar = 100 μm

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